Table 2 Enrichment analysis of housekeeping and three selected tissue-specific gene sets.
From: A comprehensive functional analysis of tissue specificity of human gene expression
Housekeeping | Retina | Testis | Adrenal Gland | |
|---|---|---|---|---|
Canonical pathways maps | Oxidative phosphorylation | Visual perception | CREM signaling in testis | Tyrosine metabolism (dopamine) |
Ubiquinone metabolism | CREB pathway | Glycolysis and gluconeogenesis | Catecholamine metabolism | |
Cytoskeleton remodeling | TGF, WNT and cytoskeletal remodeling | ATM/ATR regulation of G2/M checkpoint | Estrogen biosynthesis | |
Formation of Sin3A and NuRD complexes and their role in transcription regulation | Regulation of CDK5 in CNS | Role of APC in cell cycle regulation | Cortisone biosynthesis and metabolism | |
TGF, WNT and cytoskeleton remodeling | Role of Nek in cell cycle regulation | Rap1A regulation pathway | Androstenedione and testosterone biosynthesis and metabolism | |
Regulation activity of EIF4F | Plasmin signaling | Androgen receptor nuclear signaling | Non-genomic (rapid) action of androgen receptor | |
WNT signaling pathway | Receptor-mediated HIF regulation | Insulin regulation of fatty acid metabolism | Androgen receptor nuclear signaling | |
Role of tetraspanins in the integrin-mediated cell adhesion | Sphingolipid metabolism | Rap1B regulation pathway | WNT signaling pathway | |
BAD phosphorylation | Retinol metabolism | Nucleocytoplasmic transport of CDK/Cyclins | TGF, WNT and cytoskeletal remodeling | |
TCA | Regulation activity of EIF2 | Estrogen biosynthesis | ||
GeneGo processes | Translation_Translation initiation | Signal transduction_Visual perception | Reproduction_Spermatogenesis | Transport_Potassium transport |
Translation_Elongation-Termination | Transmission of nerve impulse | Cell cycle_Meiosis | Cell adhesion cadherins | |
Transcription_mRNA processing | Reproduction_GnRH signaling pathways | Signal transduction_CREM pathway | Development neurogenesis in general | |
Proteolysis_Ubiquitin-proteasomal proteolysis | Development_Neurogenesis in general | Reproduction_Male sex differentiation | Signal transduction NOTCH signaling | |
Translation_Regulation of initiation | Transport_Calcium transport | Signal transduction_Androgen receptor nuclear signaling | Signal transduction_Androgen receptor signaling cross talk | |
Protein folding_Folding in normal condition | Development_Neurogenesis- synaptogenesis | Cell cycle_Mitosis | Signal transduction_CREM pathway | |
Immune_Phagosome in antigen presentation | Reproduction_Progesterone signaling | Proteolysis_Ubiquitin-proteasomal proteolysis | Signal transduction_Neuropeptides signaling pathway | |
Protein folding_Protein folding nucleus | Cell adhesion_Integrin priming | Cell cycle_Core | Development ossification and bone remodeling | |
Protein folding_Response to unfolded protein | Translation_Regulation of initiation | Signal transduction_Visual perception | Muscle contraction | |
Protein folding_ER and cytoplasm | Reproduction_Male sex differentiation | Cell cycle_G2-M | Cell adhesion amyloid proteins | |
GO processes | Metabolic process | Sensory perception of light stimulus | Sexual reproduction | Feeding behavior |
Cellular metabolic process | Visual perception | Reproduction | Smooth muscle differentiation | |
Translation | Sensory perception | Spermatogenesis | Oocyte development | |
Macromolecule metabolic process | Neurological process | Male gamete generation | Oogenesis | |
Primary metabolic process | Detection of visible light | Gametogenesis | Male gonad development | |
Macromolecule biosynthetic process | Detection of light stimulus | Fertilization | Embryonic epithelial tube formation | |
Cellular protein metabolic process | Detection of abiotic stimulus | Sperm motility | Development of primary male sexual characteristic | |
Cellular macromolecule metabolic process | Phototransduction | Spermatid development | Germ cell development | |
Protein metabolic process | Detection of light stimulus during visual perception | Spermatid differentiation | Cell-cell signaling | |
Intracellular transport | Detection of light stimulus during sensory perception | Development of primary sexual characteristics | Dopamine biosynthetic process from tyrosine | |
Diseases | Neoplasm by site | Vision disorder | Infertility | Diabetes insipidus |
Breast neoplasms | Eye diseases | Infertility, male | Hypopituitarism | |
Breast disease | Retinal degeneration | Dyskeratosis congenita | Adrenal gland disease | |
Genetic disease, inborn | Sensation disorders | Dysautonomia, familial | Adrenal cortex disease | |
Digestive systems neoplasm | Night blindness | Ciliary motility disorders | Adrenal cortex neoplasm | |
Poxviridae infections | Retinitis pigmentosa | Kartagener Syndrome | Adrenal gland neoplasm | |
Lysosomal storage disease | Eye diseases, hereditary | Dextrocardia | Carcinoma, basal cell | |
Mental retardation | Retinal diseases | Herpes zoster | Neoplasm, basal cell | |
Aneuploidy | Blindness | Bronchiectasis | Myokymia | |
Vaccinia | Retinitis | Autonomic nervous system diseases | Pathologic processes |