Table 3 Correlation between PrPSc and activated cPLA2 in ScGT1 cells. The amounts of PrPSc and activated cPLA2 (phosphorylated at serine 505) in ScGT1 and GT1 cells treated for 7 days with neurotrophic factors or retinoic acid as shown. Values shown are the mean ± SD from 9 samples. PrPSc content of cells significantly greater than those of untreated cells (P < 0.05) are indicated by * and amounts of activated cPLA2 significantly greater than those of untreated cells (P < 0.05) are indicated by #.
| Â | PrPSc (ng/ml) | Activated cPLA2 (units) | ||
|---|---|---|---|---|
| Â | ScGT1 | GT1 | ScGT1 | GT1 |
Control | 6.9 ± 0.2 | - | 395 ± 33 | 100 ± 18 |
10 ng/ml BDNF | 15.2 ± 1.4* | - | 514 ± 69# | 102 ± 7 |
10 ng/ml GDNF | 14.2 ± 0.5* | - | 542 ± 65# | 109 ± 9 |
10 ng/ml NGF | 7.4 ± 1.7 | - | 416 ± 46 | 98 ± 6 |
100 nM retinoic acid | 16.5 ± 2.1* | - | 553 ± 79# | 113 ± 13 |