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Table 3 Correlation between PrPSc and activated cPLA2 in ScGT1 cells. The amounts of PrPSc and activated cPLA2 (phosphorylated at serine 505) in ScGT1 and GT1 cells treated for 7 days with neurotrophic factors or retinoic acid as shown. Values shown are the mean ± SD from 9 samples. PrPSc content of cells significantly greater than those of untreated cells (P < 0.05) are indicated by * and amounts of activated cPLA2 significantly greater than those of untreated cells (P < 0.05) are indicated by #.

From: Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2activation

  PrPSc (ng/ml) Activated cPLA2 (units)
  ScGT1 GT1 ScGT1 GT1
Control 6.9 ± 0.2 - 395 ± 33 100 ± 18
10 ng/ml BDNF 15.2 ± 1.4* - 514 ± 69# 102 ± 7
10 ng/ml GDNF 14.2 ± 0.5* - 542 ± 65# 109 ± 9
10 ng/ml NGF 7.4 ± 1.7 - 416 ± 46 98 ± 6
100 nM retinoic acid 16.5 ± 2.1* - 553 ± 79# 113 ± 13