The calcium-sensing receptor regulates parathyroid hormone gene expression in transfected HEK293 cells

Table 1 Regulation of PTH gene expression in HEK293 cells transfected with the CaR and hPTH plasmids and in the rat parathyroid by calcium

	HEK293 cells + CaR	Rat parathyroid
PTH transcription	not applicable	no effect
PTH mRNA levels	regulated	regulated
PTH mRNA stability	regulated	regulated
PTH secretion	unknown	regulated
AUF1 and KSRP-PTH mRNA interactions	regulated	regulated
AUF1 protein modifications	regulated	regulated
regulation by [Ca²⁺]_o and R568	regulated	regulated

AUF1 = AU rich binding factor; KSRP = KH domain splicing regulatory protein; PTH = parathyroid hormone

ISSN: 1741-7007