Figure 7

Genetic interaction of DmPsGEF with Rho family members. The morphology of the alpha/beta lobes of mushroom bodies in wild-type (A), rac1 ^J11 /+ (B), and dmPsGEF ^Δ21hemizygous males (C) as well as under rho1 ^E3.10 (D), rac2 ^Δ (E), mtl ^Δ (F), rac1 ^J11 (H), and pak ⁶ (I) heterozygous background is shown. To determine the interactions with Cdc42 (G), dmPsGEF ^Δ21homozygous females with cdc42 ⁴ heterozygous background were analyzed. The alpha and beta lobes are indicated by arrows in (A). The reduction of Rac1 gene dosage dramatically influences the phenotypes; a pair of alpha/beta lobes is missing in 90% of the examined animals (H).