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Figure 8 | BMC Biology

Figure 8

From: Specific retention of the protostome-specific PsGEF may parallel with the evolution of mushroom bodies in insect and lophotrochozoan brains

Figure 8

PsGEF functions as a GEF for Rac in cultured cells. HeLa cells transiently transfected with DmPsGEF RhoGEF domain expression constructs were stained with fluorescein isothiocyanate-phalloidin to detect F-actin (A and D), and anti-myc antibodies were used to detect the RhoGEF domain of DmPsGEF (B and E). The images A and B are merged to form image (C), and the images D and E are merged to form image (F). Actin polymerization in membranes, which results in membrane ruffling, is specifically observed in cells that express the RhoGEF domain of DmPsGEF (arrowheads in C and F).

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