Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

Table 10 Evidence that there are fewer alternatively spliced genes in nonsense-mediated mRNA decay under-represented functional classes in humans.

	All^a				Non-NMD^b
Biological process terms	Non-AS	AS	AS Proportion	P value	Non-AS	AS	AS proportion	P value
Developmental processes	286	1,304	0.82	1.27E-06	283	1271	0.82	1.43E-06
Cell surface receptor mediated signal transduction	224	834	0.79	3.40E-12	221	811	0.79	5.19E-12
Sensory perception	44	170	0.79	0.00699	44	165	0.79	0.00543
Signal transduction	416	2,029	0.83	2.44E-06	409	1960	0.83	2.31E-06
Chemosensory perception	5	5	0.50	0.00726	5	5	0.50	0.00767
Total genes	2,026	12,466	0.86		1987	12,047	0.86

Notes. NMD = nonsense-mediated mRNA decay. ^a all the genes with alternative splicing information were used. ^b only the genes that are not NMD candidates were used.

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