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Table 7 Test of neutral evolution for human nonsense-mediated mRNA decay-specific exons under branch model.

From: Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

Model ω (Human) ω (Mouse) ω (Dog) Log-likelihood Number of parameters P value
Free-ratios 0.3423 0.1082 0.0884 -6947.6716 7  
Free-ratios(fix) 1 0.0973 0.0732 -6963.5371 6 1.77E-08
  1. Note: if the neutral evolution occurred in human lineage, then the log-likelihood should not change much after the ω is fixed at 1. Our data reject this neutral model with a significant difference.