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Table 9 Biological process analysis of nonsense-mediated mRNA decay candidates.

From: Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

  Human Mouse
Biological process terms All genes NMD genes P value All genes NMD genes P value
Biological process unclassified 6,172 327O 1.45 × 10-11 6080 244O 1.28 × 10-11
Developmental processes 1,908 43U 1.68 × 10-3 1867 32U 5.70 × 10-2
Cell-surface receptor-mediated signal transduction 1,513 30U 3.56 × 10-3 - - -
Sensory perception 465 5U 1.08 × 10-2 971 13U 7.10 × 10-2
Signal transduction 3,127 87U 1.44 × 10-2 3491 66U 8.75 × 10-3
Chemosensory perception 203 0 6.03 × 10-2 545 2U 5.14 × 10-3
Olfaction - - - 539 2U 8.14 × 10-3
Total number of genes 18,172 693   17939 491  
  1. Notes. NMD = nonsense-mediated mRNA decay. The biological processes with Bonferroni-corrected P values < 0.1 are listed; the complete result is presented in Additional file 3. O: biological process was over-represented in NMD candidates; U: biological process was under-represented in NMD candidates; symbol '-' indicates that the biological process exhibited a P value > 0.1 in this species, but not in the other species.