Ortholog locations of the P. dumerilii ParaHox neighbouring genes in human. The top line shows a merge of the Platynereis contigs, black boxes are the ParaHox genes, and other boxes are neighbouring genes. Gene order is not biologically significant and the cluster break is denoted by double-parallel lines. The middle panel shows the locations of the human orthologs. The central large grey shaded area is the location of the ParaHox genes, and other grey shaded boxes are orthologs that are tightly linked to the human ParaHox genes. The bottom line shows probable genomic organisation around the ParaHox genes in the protostome-deuterostome ancestor, but the ordering of the genes around the ParaHox cluster is not significant in this figure, and cannot be deduced from this data. Black boxes represent homeobox genes, and ParaHox neighbours are ranked according to support with dark grey boxes being the most strongly supported, followed by light grey box and white boxes (see text for details).