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Table 1 The effect of G proteins on the doubling time of cells

From: A Dictyostelium chalone uses G proteins to regulate proliferation

 

Doubling time, hours

Cell type

Low density

High density

Wild-type

13.0 ± 0.6

35.4 ± 4.3

aprA -

9.7 ± 0.1**

20.7 ± 0.4*

cfaD -

10.9 ± 0.4*

17.7 ± 0.1**

gα2 -

13.9 ± 0.1

34.9 ± 3.3

gα5 -

12.2 ± 0.5

34.6 ± 1.3

gα7 -

12.2 ± 0.9

28.6 ± 5.4

gα8 -

10.9 ± 0.3*

13.4 ± 0.2**

gα9 -

10.1 ± 0.3**

18.3 ± 1.5**

-

11.1 ± 0.4*

24.1 ± 3.0

  1. Doubling times were calculated using the data from Figure 2. Low density doubling times were calculated for cells in the range of 2 × 105 to 5 × 106 cells/ml. High density doubling times were calculated for cells in the range of 5 × 106 to 2 × 107 cells/ml. All values are means ± SEM's from three or more independent assays. A * indicates a statistically significant difference with p < 0.05; ** indicates p < 0.01, comparing the value to the wild type value (1-way ANOVA, Dunnett's test).