Effect of [ D -Ala
, D -Leu
]-enkephalinamide (DADLE) on tumor necrosis factor (TNF)α and interleukin (IL)1β mRNA expression of the cortex exposed to ischemia/reperfusion (I/R) stress. Mean ± standard deviation (n = 6). * P < 0.05 versus the control group. #P > 0.05 versus I/R group. Note that the cerebral I/R dramatically increased the levels of TNFα and IL1β mRNA by 350% to 700%.