From: Receptor oligomerization and beyond: a case study in bone morphogenetic proteins
Ligand (analyte) | Type I receptor (immobilized) | Type II receptor (immobilized) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 | ActR-I | ActR-IB | BMPR-IA | BMPR-IB | ActR-II | ActR-IIB | BMPR-II | |||||
 | Mean | Mean | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD |
BMP-2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
k on × 10-4 [M-1s-1] | NB | NB | 50 | ± 12.1 | 25 | ± 4.37 | 370 | ± 66.6 | 280 | ± 33.6 | 150 | ± 25.5 |
k off × 103 [s-1] | NB | NB | 0.4 | ± 0.09 | 0.7 | ± 0.09 | 88 | ± 23.8 | 18 | ± 4.68 | 70 | ± 19.6 |
K D (kin) [nM] | NB | NB | 0.8 | ± 0.37 | 2.7 | ± 0.82 | 14 | ± 6.31 | 6.3 | ± 2.39 | 45 | ± 20.3 |
K D (eq) [nM] | NB | NB | NE |  | NE |  | 24 | ± 1.92 | 9.0 | ± 1.17 | 59 | ± 10.0 |
GDF-5 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
k on × 10-4 [M-1s-1] | NB | NB | 23 | ± 5.98 | 39 | ± 4.68 | 140 | ± 15.4 | 110 | ± 19.8 | 110 | ± 20.9 |
k off × 103 [s-1] | NB | NB | 4.3 | ± 0.77 | 0.5 | ± 0.16 | 28 | ± 4.48 | 4.5 | ± 0.59 | 38 | ± 8.74 |
K D (kin) [nM] | NB | NB | 19 | ± 8.36 | 1.3 | ± 0.56 | 20 | ± 5.40 | 4.0 | ± 1.24 | 36 | ± 15.1 |
K D (eq) [nM] | NB | NB | NE |  | NE |  | 32 | ± 3.84 | 5.6 | ± 0.90 | 46 | ± 8.28 |
BMP-7 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
k on × 10-4 [M-1s-1] | NE | NB | 14 | ± 2.24 | 11 | ± 2.42 | 120 | ± 20.4 | 140 | ± 30.8 | 96 | ± 14.4 |
k off × 103 [s-1] | NE | NB | 7.9 | ± 1.19 | 1.0 | ± 0.18 | 6.2 | ± 0.69 | 9.0 | ± 1.26 | 24 | ± 6.24 |
K D (kin) [nM] | > 500* | NB | 58 | ± 18.0 | 9.0 | ± 3.87 | 5.1 | ± 1.43 | 6.5 | ± 2.34 | 25 | ± 10.3 |
K D (eq) [nM] | > 500* | NB | NE |  | NE |  | 8.0 | ± 0.48 | 9.2 | ± 1.28 | 40 | ± 5.20 |
Activin-A | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
k on × 10-4 [M-1s-1] | NB | NB | NB |  | NB |  | 130 | ± 23.4 | 160 | ± 22.4 | 53 | ± 7.95 |
k off × 103 [s-1] | NB | NB | NB |  | NB |  | 7.5 | ± 1.65 | 1.7 | ± 0.14 | 29 | ± 6.96 |
K D (kin) [nM] | NB | NB | NB |  | NB |  | 5.7 | ± 2.28 | 1.1 | ± 0.24 | 59 | ± 24.2 |
K D (eq) [nM] | NB | NB | NB |  | NB |  | 6.0 | ± 0.54 | 2.1 | ± 0.15 | 24 | ± 4.08 |