Skip to main content

Table 3 Binding affinities of soluble type II receptors in ternary complexes

From: Receptor oligomerization and beyond: a case study in bone morphogenetic proteins

Type I receptor (immobilized)

Ligand (analyte I)

Type II receptor (analyte 2)

   

ActR-II

ActR-IIB

BMPR-II

BMPR-IA

BMP2

K D (eq), nM

4,200

2,800

22,000

BMPR-IB

 

SD

± 714

± 357

± 6,160

BMPR-IA

GDF5

K D (eq), nM

20,000

2,900

32,000

BMPR-IB

 

SD

± 3,660

± 339

± 5,632

BMPR-IA

BMP7

K D (eq), nM

1,500

7,000

16,000

BMPR-IB

 

SD

± 130

± 1,015

± 2,592

  1. The data obtained from binding of type II receptor ectodomains (ECDs) as analyte to the preformed complexes were fitted by equilibrium dose response K D (eq). The data represent mean values of two measurements using at least six different type II receptor concentrations.
  2. ActR = activin receptor; BMP(R) = bone morphogenic protein (receptor); GDF = growth and differentiation factor; SD = standard deviation.
Back to article page

BMC Biology

ISSN: 1741-7007

Contact us