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Table 3 Binding affinities of soluble type II receptors in ternary complexes

From: Receptor oligomerization and beyond: a case study in bone morphogenetic proteins

Type I receptor (immobilized) Ligand (analyte I) Type II receptor (analyte 2)
    ActR-II ActR-IIB BMPR-II
BMPR-IA BMP2 K D (eq), nM 4,200 2,800 22,000
BMPR-IB   SD ± 714 ± 357 ± 6,160
BMPR-IA GDF5 K D (eq), nM 20,000 2,900 32,000
BMPR-IB   SD ± 3,660 ± 339 ± 5,632
BMPR-IA BMP7 K D (eq), nM 1,500 7,000 16,000
BMPR-IB   SD ± 130 ± 1,015 ± 2,592
  1. The data obtained from binding of type II receptor ectodomains (ECDs) as analyte to the preformed complexes were fitted by equilibrium dose response K D (eq). The data represent mean values of two measurements using at least six different type II receptor concentrations.
  2. ActR = activin receptor; BMP(R) = bone morphogenic protein (receptor); GDF = growth and differentiation factor; SD = standard deviation.