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Table 1 Levels of c-Myc targets involved in ribosome biogenesis and translation

From: c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland

Targets

Relative expressiona

 

L2.5

L5.5

 

Mu-1

Mu-2

Mu-3

Mu-4

RNA Pol II products b

    

   Nucleolar proteins

    

Nucleophosmin

0.62

0.78

0.59

0.39

Nucleolin

0.58

0.93

0.65

0.26

   Large ribosomal proteins

    

L3

0.47

0.77

0.40

0.24

L6

0.56

1.08

0.44

0.32

L11

0.62

0.97

0.37

0.33

L23

0.73

0.59

0.36

0.25

   Small ribosomal proteins

    

S3

0.46

0.55

0.60

0.22

S19

0.49

0.83

0.45

0.18

   Other

    

Poly(A)-binding protein

0.60

0.73

0.74

0.56

RNA Pol I product

    

5'-external transcribed spacer of 45S pre-rRNA

0.53

1.19

0.29

0.79

RNA Pol III product

    

5S rRNA

3.08

0.41

0.28

0.38

  1. aResults are relative expression levels in mutant mice compared with levels in the corresponding wild type (WT) littermates. Four mutant mice (Mu-1 to -4) were analyzed on lactation day 2.5 and 5.5 and each value is relative to the matched WT value. bDirect targets of transcription activated by c-Myc, chosen from http://www.myc-cancer-gene.org/index.asp[46].