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Table 1 Levels of c-Myc targets involved in ribosome biogenesis and translation

From: c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland

Targets Relative expressiona
  L2.5 L5.5
  Mu-1 Mu-2 Mu-3 Mu-4
RNA Pol II products b     
   Nucleolar proteins     
Nucleophosmin 0.62 0.78 0.59 0.39
Nucleolin 0.58 0.93 0.65 0.26
   Large ribosomal proteins     
L3 0.47 0.77 0.40 0.24
L6 0.56 1.08 0.44 0.32
L11 0.62 0.97 0.37 0.33
L23 0.73 0.59 0.36 0.25
   Small ribosomal proteins     
S3 0.46 0.55 0.60 0.22
S19 0.49 0.83 0.45 0.18
   Other     
Poly(A)-binding protein 0.60 0.73 0.74 0.56
RNA Pol I product     
5'-external transcribed spacer of 45S pre-rRNA 0.53 1.19 0.29 0.79
RNA Pol III product     
5S rRNA 3.08 0.41 0.28 0.38
  1. aResults are relative expression levels in mutant mice compared with levels in the corresponding wild type (WT) littermates. Four mutant mice (Mu-1 to -4) were analyzed on lactation day 2.5 and 5.5 and each value is relative to the matched WT value. bDirect targets of transcription activated by c-Myc, chosen from http://www.myc-cancer-gene.org/index.asp[46].