Skip to main content

Table 1 Summary of gene expression changes in cell lines treated with and without DMSO and/or RA.

From: Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative β-catenin

   Cardiac Skeletal Markers  
Cell line Conditions GATA-4 Pax3 Gli2 Meox1 MRFs Figure
P19 - - - - - - Fig. 7 & Data not shown
P19 +DMSO + + + + + Figs. 1 & 4
P19 +DMSO&RA - +++ + +++ +++ Figs. 1 & 4
P19 [β-cat/EnR] +DMSO N.D. - - - - Figs. 3 & 4
P19 [β-cat/EnR] +DMSO&RA N.D. +++ +++ - - Figs. 3 & 4
P19 [BMP] - - - - - - Data not shown
P19 [BMP] +DMSO + - N.D. - - Fig. 6, 7 & 8
P19 [BMP] +DMSO&RA + +++ N.D. N.D. +++ Fig. 8
Mouse ES - + - N.D. +/- - Fig. 2
Mouse ES +RA +/- +++ N.D. +++ +++ Fig. 2
  1. P19 cell lines indicated on the right were aggregated under the conditions described and the induction of muscle marker gene expression was monitored.
  2. (+++ = high expression; + = normal expression; +/- = partial expression, - = not expressed; N.D. = not determined)