Skip to main content

Table 1 Candidate Genes for Alcohol Consumption by HXB/BXH RI Rats.

From: Genetical genomic determinants of alcohol consumption in rats and humans

Gene Symbol Gene Description Gene Location Chr(Mb) eQTL Location Chr(Mb) eQTL Mb Range eQTL LOD (p-value) bQTL Location Chr(Mb) Correlation Coefficient (p-value) Broad Sense Heritability Percent Present
Cckbr cholecystokinin B receptor 1 (163.17) 1 (168.95) 139.73-179.97 6.3 (<0.001) 1 (159-194) 0.61 (0.0023) 0.82 100%
Coq7 demethyl-Q 7 (Coenzyme q (ubiquinone) biosynthetic enzyme (DHPB methyltransferase) 7) 1 (176.76) 1 (177.64) 152.25-179.75 9.0 (<0.001)   0.55 (0.0059) 0.93 100%
Fgfr2 fibroblast growth factor receptor 2 isoform c 1 (189.48) 1 (184.63) 173.38-184.63 20.7 (<0.001)   0.58 (0.0029) 0.99 93%
Ptpre protein tyrosine phosphatase receptor type E 1 (195.16) 1 (195.13) 184.63-196.57 13.1 (<0.001)   -0.43 (0.0348) 0.95 100%
Abat 4-aminobutyrate aminotransferase 10 (7.04) 1 (132.04) 12.84-249.11 4.2 (0.027)   -0.51 (0.0267) 0.56 100%
Tpst1 tyrosylprotein sulfotransferase 1 (predicted) 12 (27.59) 1 (15.55) 9.02-205.67 3.1 (0.096)   0.51 (0.0265) 0.54 99%
Tmem2 transmembrane protein 2 1 (225.04) 1 (223.19) 39.64-254.91 3.7 (0.065) 1 (213-238) 0.53 (0.0095) 0.85 100%
Mboat2 membrane bound O-acyltransferase domain 6 (42.49) 6 (38.84) 18.53-131.90 3.5 (0.072) 6 (33-53) 0.43 (0.0455) 0.73 100%
Dynlrb1 dynein light chain roadblock-type 1 3 (145.72) 6 (38.84) 18.53-115.00 3.6 (0.095)   0.44 (0.0456) 0.66 100%
Tnk2 tyrosine kinase, no-receptor, 2 11 (69.93) 6 (25.68) 0.27-38.84 4.0 (0.010)   -0.50 (0.0212) 0.68 100%
Nek3 NIMA (never in mitosis gene a)-related expressed 16 (74.52) 6 (37.98) 25.56-37.98 4.1 (0.008)   -0.43 (0.0499) 0.69 97%
Afap1l1 actin filament associated protein 1-like 1 18 (57.71) 6 (33.80) 25.68-50.93 3.3 (0.090)   0.49 (0.0227) 0.74 100%
Mc4r melanocortin 4 receptor 18 (63.39) 6 (33.80) 33.80-50.93 3.7 (0.006)   0.46 (0.0417) 0.59 96%
Tubb6 tubulin beta 6 18 (63.92) 6 (33.80) 33.80-124.56 3.2 (0.097)   0.47 (0.0344) 0.63 98%
Spire1 spire homolog 1 18 (64.02) 6 (33.80) 18.53-98.70 3.4 (0.025)   0.53 (0.0109) 0.77 100%
Mogat2 monoacyglycerol O-acyltransferase 2 1 (156.52) 12 (34.31) 29.92-38.52 3.5 (0.028) 12 (25-46) -0.45 (0.0353) 0.78 98%
F2rl1 proteinase-activated receptor-2 G protein coupled 2 (25.89) 12 (38.52) 36.18-43.30 2.8 (0.059)   0.53 (0.0224) 0.52 52%
P2rx4 P2X purinoceptor 4 (ATP receptor) 12 (34.94) 12 (34.50) 13.40-34.50 5.1 (0.003)   -0.70 (0.0004) 0.80 100%
Rab35 RAB35 member RAS oncogene family 12 (42.23) 12 (41.98) 38.21-43.30 9.0 (<0.001)   0.45 (0.0296) 0.91 100%
Pop5 processing of precursor 5 ribonuclease P/MRP 12 (42.64) 12 (41.98) 36.18-43.30 4.4 (0.025)   -0.54 (0.0125) 0.68 100%
  1. All transcripts listed displayed an eQTL/bQTL overlap, showed a significant correlation with alcohol consumption, and passed the filters for heritability and detectability of expression.