Genetical genomic determinants of alcohol consumption in rats and humans

Table 4 Multivariate Models with Covariates for Alcohol Consumption

MONTREAL (r²= 0.62)
Effect	Estimate	Standard Error	t-statistic	p-value
Intercept	-0.59	0.13	-4.59	<.0001
recessive haplotype 2 - MPDZ	1.02	0.24	4.17	<.0001
rs701492 - GAD1 (AA)	0.70	0.10	6.94	<.0001
rs701492 - GAD1 (AB)	-0.03	0.07	-0.42	0.6714
rs701492 - GAD1 (BB)	referent
Age	0.01	0.00	4.50	<.0001
Alcohol dependence in past year	1.04	0.10	10.73	<.0001
Alcohol abuse in past year	0.73	0.10	7.67	<.0001
Family history of depression (1st degree relative)	0.50	0.09	5.45	<.0001
Familial depression and alcohol dependence*	-0.85	0.14	-6.09	<.0001
Used medication other than antidepressants in last month	0.26	0.07	3.91	0.0001
SYDNEY (r ² = 0.62)
Effect	Estimate	Standard Error	t-statistic	p-value
Intercept	0.24	0.06	4.12	<.0001
CHRM5 (recessive)	2.10	0.35	5.95	<.0001
GABRB2 (dominant)	3.03	0.43	7.00	<.0001
PPP1R1B (recessive)	2.97	0.32	9.22	<.0001
Alcohol dependence in past year	0.58	0.11	5.06	<.0001
Alcohol abuse in past year	0.58	0.11	5.14	<.0001

Shown are the coefficients associated with the final multivariate models with covariates for alcohol consumption as outcome. Final models were chosen using a backward selection process with an exit criterion of p > 0.001.
* Familial depression is defined as major depression in the subject and in a first-degree relative.

ISSN: 1741-7007