Skip to main content

Table 4 Multivariate Models with Covariates for Alcohol Consumption

From: Genetical genomic determinants of alcohol consumption in rats and humans

MONTREAL (r2= 0.62)
Effect Estimate Standard Error t-statistic p-value
Intercept -0.59 0.13 -4.59 <.0001
recessive haplotype 2 - MPDZ 1.02 0.24 4.17 <.0001
rs701492 - GAD1 (AA) 0.70 0.10 6.94 <.0001
rs701492 - GAD1 (AB) -0.03 0.07 -0.42 0.6714
rs701492 - GAD1 (BB) referent
Age 0.01 0.00 4.50 <.0001
Alcohol dependence in past year 1.04 0.10 10.73 <.0001
Alcohol abuse in past year 0.73 0.10 7.67 <.0001
Family history of depression (1st degree relative) 0.50 0.09 5.45 <.0001
Familial depression and alcohol dependence* -0.85 0.14 -6.09 <.0001
Used medication other than antidepressants in last month 0.26 0.07 3.91 0.0001
SYDNEY (r 2 = 0.62)
Effect Estimate Standard Error t-statistic p-value
Intercept 0.24 0.06 4.12 <.0001
CHRM5 (recessive) 2.10 0.35 5.95 <.0001
GABRB2 (dominant) 3.03 0.43 7.00 <.0001
PPP1R1B (recessive) 2.97 0.32 9.22 <.0001
Alcohol dependence in past year 0.58 0.11 5.06 <.0001
Alcohol abuse in past year 0.58 0.11 5.14 <.0001
  1. Shown are the coefficients associated with the final multivariate models with covariates for alcohol consumption as outcome. Final models were chosen using a backward selection process with an exit criterion of p > 0.001.
  2. * Familial depression is defined as major depression in the subject and in a first-degree relative.