MetaCore pathway analysis of differentially expressed genes of animals housed in different environments. Differentially expressed genes (P < 0.05) were imported into GeneGo MetaCore analytical software to determine significantly enriched canonical pathways in each group. Data represent the distribution in cell process categories of statistically significantly enriched pathways (P < 0.05) of the comparisons IR vs OUT (A) and IN vs OUT (B). Most pathways from both comparisons group into five categories: G-proteins; G-protein coupled receptor; congenital, hereditary and neonatal diseases and abnormalities; immune response; and development. Note that there is redundancy in category allocation.