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Table 5 MetaCore pathway analysis of differentially expressed genes of the treatment comparison IN versus OUT.

From: Environmentally-acquired bacteria influence microbial diversity and natural innate immune responses at gut surfaces

Day 5 IN vs OUT P-value Significant* Total**
Transcription_Ligand-Dependent Transcription of Retinoid-Target genes 0.00022 7 32
G-protein signalling_G-Protein alpha-s signalling cascades 0.00473 5 28
Transcription_CREM signalling in testis 0.00626 4 19
Proteolysis_Putative ubiquitin pathway 0.01076 4 22
Immune response_PGE2 signalling in immune response 0.01102 5 34
Development_Lipoxin inhibitory action on PDGF, EGF and LTD4 signalling 0.01468 4 24
Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signalling 0.01468 4 24
Cell cycle_Initiation of mitosis 0.01694 4 25
Cell cycle_Regulation of G1/S transition (part 1) 0.01748 5 38
Muscle contraction_GPCRs in the regulation of smooth muscle tone 0.02082 6 54
Day 28 IN vs OUT P -value Significant* Total**
Cytoskeleton remodeling_CDC42 in cellular processes 0.00013 7 22
Oxidative stress_Role of ASK1 under oxidative stress 0.00013 7 22
Immune response_Histamine H1 receptor signalling in immune response 0.00028 9 40
Development_VEGF signalling and activation 0.00044 8 34
Cytoskeleton remodeling_TGF, WNT and cytoskeletal remodeling 0.00079 15 107
Cytoskeleton remodeling_Cytoskeleton remodeling 0.00079 14 96
Immune response_IL-3 activation and signalling pathway 0.00108 7 30
Immune response_Histamine signalling in dendritic cells 0.00118 8 39
Development_TGF-beta receptor signalling 0.00135 9 49
Signal transduction_Activation of PKC via G-Protein coupled receptor 0.00267 8 44
Day 56 IN vs OUT P -value Significant* Total**
Peroxisomal branched chain fatty acid oxidation 0.00004 8 22
Cholesterol Biosynthesis 0.00024 7 21
Neurophysiological process_Dopamine D2 receptor transactivation of PDGFR in CNS 0.00068 6 18
Propionate metabolism p.1 0.00196 5 15
Development_Angiotensin signalling via beta-Arrestin 0.00281 6 23
G-protein signalling_G-Protein alpha-12 signalling pathway 0.00448 7 33
Delta508-CFTR traffic/ER-to-Golgi in CF 0.00783 4 13
G-protein signalling_Rap2B regulation pathway 0.00783 3 7
Development_Mu-type opioid receptor signalling via Beta-arrestin 0.00962 5 21
Mitochondrial unsaturated fatty acid beta-oxidation 0.01709 4 16
  1. Differentially expressed genes (P < 0.05) were imported into GeneGo MetaCore analytical software to determine the significantly enriched canonical pathways in the treatment comparison IN vs OUT. The top ten pathways for each comparison are shown, with the number of genes assigned to each pathway, and the corresponding P-value.
  2. * The number of genes on each map that are differentially expressed in the specific treatment comparison
  3. ** The total number of genes on each map