
1

2

3

4

5

6

7

8

9


1
         
2

0.520
        
3

2.672

2.440
       
4

3.995

2.139

5.286
      
5

4.294

2.058

7.457

7.629
     
6

2.155

2.696

4.855

4.261

5.158
    
7

3.378

2.240

3.593

2.973

3.250

2.983
   
8

2.160

2.807

2.807

2.215

2.125

2.051

3.806
  
9

2.091

2.241

2.087

2.093

2.800

2.711

2.306

2.372
 
 1. Saccharomyces cerevisiae virus La (LBC)
 2. Black raspberry virus F
 3. Debaryomyces hansenii Cp1
 4. D. hansenii Cp2
 5. Penicillium marneffei
 6. Pichia stipitis Cp4
 7. P. stipitis Cp2
 8. P. stipitis Cp3
 9. P. stipitis Cp1
 The test statistic (dN  dS) is shown where dS and dN are the numbers of synonymous and nonsynonymous substitutions per site. The variance of the difference was computed using the bootstrap method (500 replicates). Analyses were conducted using the Kumar method in MEGA4. All negative values have a P value of less than 0.05 and are considered significant. The negative values indicate rejection of the hypothesis of strict neutrality in the direction of purifying selection (a negative dNdS). Significance for the viral contrast (1 versus 2) could not be calculated because the evolutionary distance could not be calculated. The key to the cell numbers is given below the table.