Table 2 Zebrafish mutants used for the analysis of visuomotor function
From: Focusing on optic tectum circuitry through the lens of genetics
Mutant | Alleles | Phenotype | Gene | Gene product | References |
|---|---|---|---|---|---|
lakritz | lak th241c | Absence of RGCs and complete blindness; no known developmental defect outside the retina | atoh7 (ath5) | Atonal homolog 7 | [66] |
blumenkohl | blutc257z , blus391 | Synaptic transmission defect in retinotectal axons; enlarged tectal receptive fields; reduced visual acuity | slc17a6b (vglut2a) | Vesicular glutamate transporter 2a | [16] |
belladonna | beltv42, bels385 , belb700 | Incomplete crossing of retinal axons, reversed eye movements, 'looping' swim behavior | lhx2b | LIM-domain homeobox factor 2b | |
double indemnity | didys390 , didys552 | Reversible depletion of saccadic eye movements | scn1lab | Voltage-gated sodium channel NaV1.6 | [60] |