The G Protein regulators EGL-10 and EAT-16, the Giα GOA-1 and the Gqα EGL-30 modulate the response of the C. elegansASH polymodal nociceptive sensory neurons to repellents

Table 1 Delay in avoidance response

Genotype	Responding (%)	Response delay in seconds (means ± SEM)	Number of worms	Repellent
N2	88	1.19 ± 0.10	100
egl-10	48*	2.83 ± 0.17*	100
egl-10;psra-6::egl-10	83**	1.90 ± 0.18**	90	1 M glycerol
dgk-1	92	1.14 ± 0.08	80
egl-10;dgk-1	78**	1.32 ± 0.09**	80
psra-6::TRPV1	100	2.56 ± 0.16	90	50 μM capsaicin
egl-10;psra-6::TRPV1	88°	4.48 ± 0.20***	90

Dry drop test (see Methods). Responding animals are those that begin backward movement within 7 seconds from encountering the repellent. *Difference from N2, P < 0.01; **difference from egl-10(md176), P < 0.01; ***difference from psra-6::TRPV1, P < 0.01.

ISSN: 1741-7007