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Figure 1 | BMC Biology

Figure 1

From: How the vertebrates were made: selective pruning of a double-duplicated genome

Figure 1

A simplified schematic diagram of the 2R quadruplication and subsequent gene fates. A model gene encoding a two-domain protein is duplicated twice. Each of the top two copies loses one domain (function) during subfunctionalization; together they make up the function of the ancestral form. Another copy acquires a new domain and thus a new function (neofunctionalization). The last copy fails to serve a unique function and is lost. A similar process can cause loss and gain of expression regulatory elements.

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