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Table 2 Top 20 gene families expanded in the course of 2Ra

From: 2R and remodeling of vertebrate signal transduction engine

TreeFam ID Number of duplication nodes Description
TF106341 19 T-box TF
TF105391 13 Integrin, alpha
TF106499 11 Gonadotropin-releasing hormone receptor/arginine vasopressin receptor
TF101109 10 Cell division control protein 42 homolog
TF105310 10 Wingless-type MMTV integration site family
TF105452 10 Annexin
TF106408 10 PDZ and LIM domain protein
TF105128 8 Dual-specificity phosphatase 3/14/18/19/21/26
TF102004 7 Protein kinase A/C
TF102023 7 Caspase family, apoptosis-related cysteine protease
TF105094 7 Cytochrome P450, family 11/24/27
TF105122 7 Dual-specificity phosphatase 1/2/4-7/9/10
TF105049 6 Heat shock 27-kDa protein/crystallin, alpha
TF105100 6 Mitogen-activated protein kinase 8-14
TF105191 6 ATP-binding cassette, subfamily A (ABC1), member 1-4/7/12/13
TF105392 6 Integrin, beta
TF101079 5 Septin 1/2/4/5/7
TF102003 5 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
TF102031 5 Phosphoinositide 3-kinase, class I/II
TF105272 5 B-cell translocation gene
  1. aFamilies which underwent expansion consist predominantly of genes encoding TFs and signalling proteins. 2R, two rounds; MMTV, mouse mammary tumor virus.