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Table 1 Cytotoxicity was analysed by MTT assay in LNCaP-S14 and IMR90 cells treated with increasing concentrations (0.01 - 40 μM) of the respective small molecule inhibitors of p27 depletion (SMIPs) for 72 h.

From: Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells

  LNCaP-S14 IMR90
MG132 0.379 0.445
Thapsigargin 0.0078 0.031
SMIP001 4.63 > 20
SMIP002 11.09 > 40
SMIP003 15.92 65.36
SMIP004 1.09 > 20
SMIP005 1.71 17.38
SMIP006 6.63 NT
SMIP009 > 40 > 40
SMIP011 > 40 ~ 40
SMIP012 4.59 ~ 10
SMIP013 18.15 ~ 20
SMIP015 13.02 ~ 20
SMIP016 14.63 4.41
SMIP017 23.73 > 40
SMIP018 > 40 > 40
SMIP019 NT ~ 40
  1. NT: not tested.
  2. The data in the table represents the IC50 (μM).