Table 2 Cell cycle distribution in protein prostate cancer cell lines treated with 40 μM small molecule inhibitors of p27 depletion (SMIPs) for 24 and 48 h.
| Â | Â | Â | LNCaP | Â | LNCaP -S14 | Â | Â | DU145 | Â | PC3 | Â | Â | IMR90 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Time | SMIP | G1 | S | G2 | G1 | S | G2 | G1 | S | G2 | G1 | S | G2 | G1 | S | G2 |
24 h | DMSO | 70.8 | 18.0 | 10.9 | 64.8 | 23.3 | 10.6 | 40.5 | 44.0 | 15.3 | 42.2 | 26.7 | 30.0 | 67.2 | 16.6 | 16.2 |
| Â | SMIP001 | 84.5 | 6.6 | 7.6 | 84.8 | 7.2 | 6.3 | 65.6 | 23.9 | 9.7 | 48.6 | 20.4 | 29.7 | 68.4 | 16.2 | 15.3 |
| Â | SMIP004 | 81.7 | 7.9 | 9.8 | 72.3 | 19.1 | 7.1 | 75.7 | 14.1 | 8.0 | 58.5 | 14.3 | 25.7 | 68.6 | 18.2 | 13.2 |
48 h | DMSO | 70.4 | 17.8 | 10.0 | 66.4 | 22.3 | 7.5 | 50.7 | 29.8 | 17.7 | 46.3 | 20.8 | 31.2 | 77.0 | 12.8 | 10.3 |
| Â | SMIP001 | 83.6 | 8.5 | 6.6 | 86.8 | 6.9 | 3.5 | 71.1 | 13.4 | 13.6 | 57.5 | 13.6 | 27.8 | 77.0 | 8.9 | 14.1 |
| Â | SMIP004 | 87.3 | 3.5 | 6.6 | 75.8 | 14.7 | 6.4 | 79.7 | 9.0 | 10.4 | 65.8 | 8.5 | 24.3 | 77.6 | 11.5 | 10.9 |