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Table 2 Cell cycle distribution in protein prostate cancer cell lines treated with 40 μM small molecule inhibitors of p27 depletion (SMIPs) for 24 and 48 h.

From: Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells

    LNCaP   LNCaP
-S14
   DU145   PC3    IMR90
Time SMIP G1 S G2 G1 S G2 G1 S G2 G1 S G2 G1 S G2
24 h DMSO 70.8 18.0 10.9 64.8 23.3 10.6 40.5 44.0 15.3 42.2 26.7 30.0 67.2 16.6 16.2
  SMIP001 84.5 6.6 7.6 84.8 7.2 6.3 65.6 23.9 9.7 48.6 20.4 29.7 68.4 16.2 15.3
  SMIP004 81.7 7.9 9.8 72.3 19.1 7.1 75.7 14.1 8.0 58.5 14.3 25.7 68.6 18.2 13.2
48 h DMSO 70.4 17.8 10.0 66.4 22.3 7.5 50.7 29.8 17.7 46.3 20.8 31.2 77.0 12.8 10.3
  SMIP001 83.6 8.5 6.6 86.8 6.9 3.5 71.1 13.4 13.6 57.5 13.6 27.8 77.0 8.9 14.1
  SMIP004 87.3 3.5 6.6 75.8 14.7 6.4 79.7 9.0 10.4 65.8 8.5 24.3 77.6 11.5 10.9
  1. The data is representative of two independent experiments.