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Table 4 Cytotoxicity was assessed by MTT assay in prostate cancer cell lines and normal fibroblasts treated with increasing concentrations (0.01 - 80 μM) of the respective small molecule inhibitors of p27 depletion (SMIPs) for 72 h and 96 h.

From: Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells

  SMIP001 SMIP004
Cell line 72 h 96 h 72 h 96 h
LNCaP-WT 47.1 32.7 40 2.4
PC3 ~ 80 80 NE NE
DU145 ~ 40 32.5 NE NE
IMR90 40-80 40-80 NE NE
  1. NE: No effect.
  2. The data in the table represents the IC50 (μM). NE: No effect.