Table 4 Cytotoxicity was assessed by MTT assay in prostate cancer cell lines and normal fibroblasts treated with increasing concentrations (0.01 - 80 μM) of the respective small molecule inhibitors of p27 depletion (SMIPs) for 72 h and 96 h.
| Â | SMIP001 | SMIP004 | ||
|---|---|---|---|---|
Cell line | 72 h | 96 h | 72 h | 96 h |
LNCaP-WT | 47.1 | 32.7 | 40 | 2.4 |
PC3 | ~ 80 | 80 | NE | NE |
DU145 | ~ 40 | 32.5 | NE | NE |
IMR90 | 40-80 | 40-80 | NE | NE |