Integrating transcriptional and signaling networks. The figure illustrates the integration method proposed by Wang and Chen . First the candidate gene regulatory network and signaling regulatory pathways are retrieved. These candidate networks are then pruned and combined, utilizing gene-expression data with time profiles to obtain an integrated and focused network under a specific condition of interest. Transcription factors serve as the interface to link the two types of networks. GO, Gene Ontology; SGD, Saccharomyces Genome Database; TF, transcription factor.