TY - JOUR AU - Yuzenkova, Yulia AU - Bochkareva, Aleksandra AU - Tadigotla, Vasisht R. AU - Roghanian, Mohammad AU - Zorov, Savva AU - Severinov, Konstantin AU - Zenkin, Nikolay PY - 2010 DA - 2010/05/07 TI - Stepwise mechanism for transcription fidelity JO - BMC Biology SP - 54 VL - 8 IS - 1 AB - Transcription is the first step of gene expression and is characterized by a high fidelity of RNA synthesis. During transcription, the RNA polymerase active centre discriminates against not just non-complementary ribo NTP substrates but also against complementary 2'- and 3'-deoxy NTPs. A flexible domain of the RNA polymerase active centre, the Trigger Loop, was shown to play an important role in this process, but the mechanisms of this participation remained elusive. SN - 1741-7007 UR - https://doi.org/10.1186/1741-7007-8-54 DO - 10.1186/1741-7007-8-54 ID - Yuzenkova2010 ER -