Figure 1From: Altered cell cycle regulation helps stem-like carcinoma cells resist apoptosisCancer stem cells (CSCs) escape apoptosis by upregulating G2/M checkpoint proteins, leading to a longer G2 phase and perhaps a longer window for DNA repair. Following chemo- or radiotherapy, all cells undergo DNA damage, but the extended G2 phase in CSCs means that they have more time to repair the damage and are thus more resistant to apoptosis.Back to article page