Statistical analysis of the cancer datasets on the phylostratigraphic map. Phylostratigraphic representation of log-odds statistics of human cancer genes, based on four different compilations (see inset on top right). Arrows designate the strongest significant over-representations. Statistical significance of the deviations were tested by a two-tailed hypergeometric test corrected for multiple comparison by a false discovery rate at 0.05 level (* P < 0.05; ** P < 0.01; *** P < 0.001). Significant over-representations and under-representations are shaded in red and blue, respectively.