Table 2 Published studies analyzing parental strains using the QTL/Microarray approach in mouse
From: Serious limitations of the QTL/Microarray approach for QTL gene discovery
| Â | Phenotype | QTL Mapping | Microarray Experiment | References | |||
|---|---|---|---|---|---|---|---|
| Â | Â | Design | Strains | Design | Tissues | Platform | Â |
| Â | Targeted custom arrays | ||||||
| Â | Arthritis | Congenic | RIIIS/J, B10.RIII | Congenic | Lymph nodes, spleen, paws | Custom | [100] |
| Â | Obesity | Congenic | SPRET/Ei, C57BL/6J | Parental | Brain, EWAT, GSM, liver | Nimblgen | [101] |
| Â | Whole-Genome arrays | ||||||
• | Alcohol addiction | RIL | HAFT, LAFT | Parental | Brain | MGU74A | |
• | Alcohol addiction | RIL | C57BL/6J, DBA/2J | Parental | NAC, PFC, VTA | U74Av2 | [103] |
| Â | Alcohol addiction | Congenic | ISS.ILS.Lore, ISS | Parental | CR | MO430A, MOE430B | |
• | Anxiety | Knockout/congenic | B6.129-Il10-/-, C57BL/6J | Congenic | ABR | MOE430 | [105] |
| Â | Anxiety | Database | - | Parental | PFC, VS, TL, PG, CR | Spotted | [106] |
• | Arthritis | AIL | DNA/1J, FVB/N | Parental | Lynph nodes | MOE430A | [107] |
| Â | Arthritis | AIL | DNA/1J, FVB/N | Parental | Lynph nodes | U430A | [36] |
• | EIAD | F2/RIL | DBA/1, C57BL/6J | Extremes | Lung | NIA15k | [52] |
• | Gallstones | BC | C57L/J, AKR/J | Parental | Liver | Spotted | |
• | HSCP | RIL, BC, Congenic | C57BL/6J, DBA/2J | Parental | HSC | Filter | [49] |
• | IBD | BC | B6-Il10-/-, C3H-Il10-/- | Congenic | Colon | U74Av2 | |
| Â | Lung injury response | BC | A/J, C57BL/6J | Parental | Lung | Spotted | [29] |
• | Macronutrient intake | Congenic | C57BL/6J, CAST/EiJ | Congenic | Liver, hypothalamus | ABI | [103] |
• | Obesity | Congenic | F-line, L-line | Congenic | Liver, BAT | Spotted | [111] |
• | Obesity | BC | C57BL/6J, SPRET/Pt, SPRET/Ei | Extremes | EWAT | Spotted | [112] |
• | Obesity | F2 | DU6i, DBA/2 | Parental | EWAT | Mu11k | [47] |
• | Osteoporosis | Congenic | C57BL/6J, CAST/Ei | Congenic | Femur | Spotted | |
| Â | Osteoporosis | RI | C57BL/6J, CAST/Ei | Parental | Kidney | Spotted | |
| Â | Platelet count | F2 | CBA/CaH, QSi5 | Parental | Liver, kidney, spleen | Spotted/Compugen Mouse 22K | [25] |
• | Pulmonary capacity | F2/BC | C3H/HeJ, JF1/Msf | Parental | Lung | Spotted/Operon | [114] |
| Â | TR | BC/Introgression | A/J, C57BL/6J | Parental | Liver, kidney, spleen | MG-430v2 | |
• | Type I diabetes | Congenic | NOD, Idd3, Idd5, Idd3+5, Idd9, B10, B10.H2g7, B10.H2g7Idd3 | Congenic | Thymus, Spleen | Affy.Eos.Custom | [116] |