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Table 4 Significance of the over/under-representation of orthologues of Saccharomyces cerevisiae haploinsufficient (HI) genes on the mating-type chromosomes of ascomycetes and the sex chromosomes of animals

From: Haploinsufficiency and the sex chromosomes from yeasts to humans

Organism Predominant lifecycle phase Mating-type or sex determination system Orthologues of Saccharomyces cerevisiae HI genes on the mating-type/sex chromosome(s)
    P value for over-representation
Saccharomyces cerevisiae Diploid Bipolar sexuality <10-50
Saccharomyces castellii Diploid Bipolar sexuality <10-10
Candida glabrata Diploid Bipolar sexuality <10-10
Saccharomyces kluyveri Diploid Bipolar sexuality <10-12
Kluyveromyces lactis Haploid Bipolar sexuality <10-19
Ashbya gossypii Haploid Bipolar sexuality 0.02
Candida albicans Diploid Asexual 0.8
Candida dubliniensis Diploid Asexual 0.6
Debaryomyces hansenii Haploid Bipolar sexuality 0.05
Yarrowia lipolytica Haploid Bipolar sexuality 0.002
    P value for under-representation
Homo sapiens Diploid X/Y 0.02
Pan troglodytes Diploid X/Y 0.04
Mus musculus Diploid X/Y 0.05
Rattus norvegicus Diploid X/Y 0.04
Equus caballus Diploid X/Y 0.01
Bos taurus Diploid X/Y 0.3
Canis familiaris Diploid X/Y 0.02
Gallus gallus Diploid Z/W 0.3
Drosophila melanogaster Diploid X/Y 0.9
Caenorhabditis elegans Diploid X/0 0.02