Relationship of isomin domain organization to that of conventional IF proteins. (a) Schematic model for the domain organization of an IF protein. Boxes: helical domains with coiled-coil forming propensity. Lines: non-α-helical domains. (b) Number of amino acids harbored by individual subdomains. HVim: human vimentin; Dm0: Drosophila melanogaster lamin Dm0. The isomin sequence was analysed using NetSurfP server (Protein Surface Accessibility and Secondary Structure Predictions, Technical University of Denmark).