Figure 1

The autophagic and endolysosomal pathways intersect and interconnect. Schematic drawing showing the autophagy process with phagophore and autophagosome formation followed by fusion of autophagosomes either directly to lysosomes to form autophagosomes, or to late endosomes to give amphisomes that subsequently fuse with lysosomes. Lipidated LC3-II, used as a marker for autophagy, is tightly associated with the autophagosomes. Note that Rab7, used as a marker of the endolysosomal pathway, is involved in both the autophagic and endolysosomal pathways.