Sequence/Site | 1 | 2 | 3 | 4 |
---|
I | A | V | A | C |
II | A | V | C | D |
III | T | Y | D | E |
IV | T | Y | E | C |
- Sites 1 and 2 are truly covarying, while sites 3 and 4 are random and unrelated. However, as sites 3 and 4 have higher entropy values than sites 1 and 2, the resulting mutual information between sites 3 and 4 is also higher than that between sites 1 and 2 (see main text for the calculations).