Figure 5

Model showing the proposed relationship between Myc and the insulin and TOR signaling pathways. AA: amino acids; DILPs: Drosophila insulin-like peptides; IRS: insulin-receptor substrate; PI3K: phosphatidylinositol-3 kinase; Rheb: Ras homolog enriched in brain; S6K: p-70-S6 ribosomal protein kinase; TSC: tuberous sclerosis complex; TOR: target of rapamycin.