Skip to main content

Table 1 Genetic interaction between Myc and components of insulin and target of rapamycin signaling.

From: Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

Genotype Total number ommatidia Ommatidium cell size (μm2) % numbera %
cell sizeb
ey- dm + /Y; +/+; +/+ 726 ± 17 (15) 239 ± 14 (15) 100 100
ey- dm + /Y; UAS-Dp110/+ 811 ± 31 (06) * 329 ± 10 (06) * 112 138
ey- dm + /Y; UAS-PTEN/+ 538 ± 25 (13) * 220 ± 11 (09) * 074 092
ey- dm + /Y; UAS-S6K/+ 692 ± 37 (10) ** 251 ± 12 (11) ** 095 105
ey- dm + /Y; UAS- Rheb -AV4 /+ 555 ± 18 (06) * 452 ± 19 (06) * 076 189
ey- dm + /Y; UAS-TOR- TED /+ 579 ± 55 (11) * 214 ± 13 (11) * 080 089
ey- dm P0 /Y; +/+; +/+ 735 ± 16 (12) 218 ± 09 (12) 100 100
ey- dm P0 /Y; UAS-Dp110/+ 703 ± 41 (06) ** 293 ± 12 (06) * 096 135
ey- dm P0 /Y; UAS-PTEN/+ 450 ± 16 (06) * 140 ± 09 (06) * 061 064
ey- dm P0 /Y; UAS-S6K/+ 684 ± 35 (09) * 216 ± 15 (13) 093 099
ey- dm P0 /Y; UAS- Rheb -AV4 /+ 651 ± 31 (07) * 335 ± 09 (09) * 088 154
ey- dm P0 /Y; UAS-TOR- TED /+ n.d. n.d. n.d. n.d.
ey- dm 4 /Y; +/+; +/+ 650 ± 44 (17) 179 ± 11 (10) 100 100
ey- dm 4 /Y; UAS-Dp110/+ 641 ± 66 (11) 228 ± 08 (06) * 100 127
ey- dm 4 /Y; UAS-PTEN/+ 458 ± 42 (06) * 120 ± 13 (06) * 070 067
ey- dm 4 /Y; UAS- Rheb- AV4 /+ 647 ± 29 (12) 238 ± 22 (08) * 100 132
ey- dm 4 /Y; UAS-TOR- TED /+ n.d. n.d. n.d. n.d.
  1. Standard deviations (±) are calculated based on the total number of the animals (reported in parenthesis); aPercentage of increase in size compared to relative control (100); b Percentage increase in cell number compared to relative control (100); p-values calculated using a Student t test: * P < 0.001; ** P < 0.05; n.d. = not determined. Of note: overexpression of PTEN in ey-dmP0/Y animals resulted in a misshaped eye phenotype (Figure 4A, Panel c') with a 98% penetrance, which might have led to an underestimation of the total number of ommatidia and therefore affected our statistical analysis.
\