Replication profiles of checkpoint mutants suggest that scaling does not require an intact checkpoint. A). Replication profile of chromosome XI. Same as Figure 1A for the indicated strains (sml1Δ, sml1Δ mec1Δ, sml1Δ rad53Δ,sml1Δ mec1Δ clb5Δ, sml1Δ mec1Δ dpb3 and sml1Δ mec1Δ sic1Δ). B). Profile sharpness defined by height of local maximas and local minimas: Same as Figure 1D for the indicated strains. C). Profile sharpness defined by decay of autocorrelation: Same as Figure 1E for the indicated strains.