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Table 1 Summary of significant changes in weight and proportions of adult mice

From: Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1genes

Tissues 3- to 6-month-old males >6- to 9-month-old males 3- to 6-month-old females >6-to 9-month-old females
Body weight ns Grb10 ↑ (vs WT and Dlk1) ns ns
Pancreas Grb10 andDKO ↑ (vs Dlk1) Grb10 and DKO ↑ (vs WT & Dlk1) ns DKO ↑ (vs Dlk1)
Pancreas % DKO ↑ (vs Dlk1) DKO ↑(vs Dlk1) ns DKO ↑ (vs Dlk1)
Grb10 ↑ (vs WT and Dlk1)
Kidneys Grb10 and DKO ↓ (vs WT) ns Grb10 and DKO ↓ (vs WT) ns
Kidneys % ns ns Grb10 and DKO ↓ (vs WT) ns
Gonadal fat ns Dlk1 ↑ (vs DKO) ns Grb10 ↓ (vs WT and Dlk1)
Gonadal fat % ns Dlk1 ↑ (vs DKO) ns ns
Renal fat ns Dlk1 ↑ (vs WT, Grb10 and DKO) ns ns
Renal fat % ns Dlk1 ↑ (vs WT, Grb10 and DKO) ns ns
Liver % Grb10 and DKO ↓ (vs DLk1) ns ns ns
Testes Dlk1 ↓ (vs WT and Grb10) NA Grb10 ↑ (vs WT and Dlk1) NA
  1. Cohorts of mice were analysed at ages 3 to 6 months and >6 to 9 months. Indicated are increases (↑) and decreases (↓) in wet weight or weight of organs expressed as a proportion of body weight (%), with comparison groups stated in brackets. Genotypes have been abbreviated such that Grb10 m/+ is represented as Grb10, Dlk1 +/p as Dlk1 and Grb10 m/+/Dlk1 +/p (or double knockouts) as DKO. Data were subject to one way ANOVA with Tukey’s post-hoc analysis and only significant differences (P <0.05 or less) are shown. For 3- to 6-month-old males, WT n = 7, Dlk1+/p n = 6, Grb10m/+ n = 6, Grb10m/+/Dlk1+/p n = 6; 3- to 6-month-old females WT n = 7, Dlk1+/p n = 6, Grb10m/+ n = 6, Grb10m/+/Dlk1+/p n = 7; >6- to 9-month-old males WT n = 7, Dlk1+/p n = 6, Grb10m/+ n = 6, Grb10m/+/Dlk1+/p n = 6; >6- to 9-month-old females WT n = 6, Dlk1+/p n = 6, Grb10m/+ n = 6, Grb10m/+/Dlk1+/p n = 5. ANOVA, analysis of variance; NA, not applicable; ns, no significant differences (P >0.05); vs, versus; WT, wild type.