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Table 1 Summary of significant changes in weight and proportions of adult mice

From: Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1genes

Tissues

3- to 6-month-old males

>6- to 9-month-old males

3- to 6-month-old females

>6-to 9-month-old females

Body weight

ns

Grb10 ↑ (vs WT and Dlk1)

ns

ns

Pancreas

Grb10 andDKO ↑ (vs Dlk1)

Grb10 and DKO ↑ (vs WT & Dlk1)

ns

DKO ↑ (vs Dlk1)

Pancreas %

DKO ↑ (vs Dlk1)

DKO ↑(vs Dlk1)

ns

DKO ↑ (vs Dlk1)

Grb10 ↑ (vs WT and Dlk1)

Kidneys

Grb10 and DKO ↓ (vs WT)

ns

Grb10 and DKO ↓ (vs WT)

ns

Kidneys %

ns

ns

Grb10 and DKO ↓ (vs WT)

ns

Gonadal fat

ns

Dlk1 ↑ (vs DKO)

ns

Grb10 ↓ (vs WT and Dlk1)

Gonadal fat %

ns

Dlk1 ↑ (vs DKO)

ns

ns

Renal fat

ns

Dlk1 ↑ (vs WT, Grb10 and DKO)

ns

ns

Renal fat %

ns

Dlk1 ↑ (vs WT, Grb10 and DKO)

ns

ns

Liver %

Grb10 and DKO ↓ (vs DLk1)

ns

ns

ns

Testes

Dlk1 ↓ (vs WT and Grb10)

NA

Grb10 ↑ (vs WT and Dlk1)

NA

  1. Cohorts of mice were analysed at ages 3 to 6 months and >6 to 9 months. Indicated are increases (↑) and decreases (↓) in wet weight or weight of organs expressed as a proportion of body weight (%), with comparison groups stated in brackets. Genotypes have been abbreviated such that Grb10 m/+ is represented as Grb10, Dlk1 +/p as Dlk1 and Grb10 m/+/Dlk1 +/p (or double knockouts) as DKO. Data were subject to one way ANOVA with Tukey’s post-hoc analysis and only significant differences (P <0.05 or less) are shown. For 3- to 6-month-old males, WT n = 7, Dlk1+/p n = 6, Grb10m/+ n = 6, Grb10m/+/Dlk1+/p n = 6; 3- to 6-month-old females WT n = 7, Dlk1+/p n = 6, Grb10m/+ n = 6, Grb10m/+/Dlk1+/p n = 7; >6- to 9-month-old males WT n = 7, Dlk1+/p n = 6, Grb10m/+ n = 6, Grb10m/+/Dlk1+/p n = 6; >6- to 9-month-old females WT n = 6, Dlk1+/p n = 6, Grb10m/+ n = 6, Grb10m/+/Dlk1+/p n = 5. ANOVA, analysis of variance; NA, not applicable; ns, no significant differences (P >0.05); vs, versus; WT, wild type.