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Table 3 G4 motif association with high Pfh1 and Cdc20 occupancy

From: The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage

G4 Status Pfh1 Status Number of motifs Number with Cdc20 % with Cdc20 P -value
G4 with Pfh1 Expressed 90 36 40% 1.5E-17
G4 w/o Pfh1 Expressed 356 14 4%  
G4 with Pfh1 Depleted 90 39 43% 1.9E-11
G4 w/o Pfh1 Depleted 356 38 11%  
  1. G4 motifs associated with high Pfh1 occupancy are significantly more likely to be associated with replication fork pausing as indicated by high Cdc20 occupancy in both Pfh1-expressing (P = 1.5E-17) (Pfh1 status expressed) and Pfh1-depleted (Pfh1 status depleted) cells (P = 1.9E-11). G4, G-quadruplex.