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Table 4 The association between G4 motifs, replication fork pausing and DNA damage is Pfh1 dependent

From: The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage

G4 Status

Pfh1 Status

Number of motifs

Number with high γH2A

% with high γH2A

P -value

G4 motifs with high Cdc20

Expressed

50

11

22%

0.23

G4 motifs w/o high Cdc20

Expressed

396

66

17%

 

G4 motifs with high Cdc20

Depleted

77

48

62%

8.7E-6

G4 motifs w/o high Cdc20

Depleted

369

129

35%

 
  1. In Pfh1-depleted cells (Pfh1 status depleted), G4 motifs associated with replication fork pausing (high Cdc20) were much more likely to result in DNA damage (high γH2A occupancy) than G4 motifs that were not associated with fork pausing. Fisher’s exact test was used to calculate P-values. G4, G-quadruplex.