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Figure 3 | BMC Biology

Figure 3

From: Nucleosome organizations in induced pluripotent stem cells reprogrammed from somatic cells belonging to three different germ layers

Figure 3

Nucleosome occupancy at the binding sites of pluripotency-related transcription factors, protein regulators and enzymes. A) The binding sites of the pluripotency transcription factors (Oct4, Sox2 and Nanog), the pluripotency regulator Smad1 in the BMB signaling pathway and the chromatin remodeler Chd7 were nucleosome depleted. B) The binding sites of self-renewal regulators (Esrrb, Tcfcp2l1 and Zfx), the PRC2 component Suz12, the coactivator p300 and Stat3 in the LIF signaling pathway were enriched on nucleosomes. C) The binding sites of the insulator-binding protein CTCF resided in the linker region with nucleosomal periodicity. D) The binding sites of factors E2F1 and c-Myc were enriched at the borders of the nucleosomes.

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