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Figure 8 | BMC Biology

Figure 8

From: Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation

Figure 8

Development of the dorsal root ganglia depends on varying functions of β-catenin during sensory neurogenesis. Simplified scheme illustrating the genetic cascades that control sensory neurogenesis [26] and their dependency on functions of β-catenin. The expression of Neurog2 specific for the first wave of neurogenesis and expression of Krox20 specific for the third wave depends on β-catenin to induce TCF/Lef-mediated transcription (green dashed line arrows). Furthermore, proliferation for late migratory and early postmigratory cells depends on one or more downstream factors of TCF/Lef transactivation (green dashed line arrows). Expression of Neurog1 as well as proliferation of postmigratory cells from E11 onwards depends on a function of β-catenin independent of its role to induce TCF/Lef transcription or to constitute cadherin-mediated cell-cell adhesion. E, embryonic day.

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