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Table 1 Kinetics of binding of CL-K1 to glycoproteins

From: Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome

Glycoprotein k on k off K D
(M −1 s −1 ) (s −1 ) (nM)
Mannan 1.6 ± 0.3 × 103 <1.0 × 10−6 <0.8
1.0 ± 0.2 × 106 3.0 ± 0.2 × 10−4 0.31 ± 0.9
Invertase 6.8 ± 0.4 × 104 1.2 ± 0.2 × 10−3 18 ± 4
6.7 ± 0.5 × 105 <1.0 × 10−6 <0.002
gp120 1.5 ± 0.3 × 105 1.1 ± 0.2 × 10−3 8 ± 4
>1 × 106 <1.0 × 10−6 <0.001
  1. All data were fitted to a two-complex binding model. Values of k on above 1 × 106 M−1 s−1 and k off below 1.0 × 10−6 s−1 exceed the reliable detection limits of the instrument, so are given as lower and upper limits respectively. Data are mean ± error from two experiments.