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Fig. 2 | BMC Biology

Fig. 2

From: Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

Fig. 2

Glucose-stimulated insulin secretion. At basal levels of blood glucose (left-hand panel), the ATP-sensitive K+ channels (KATP channels) in pancreatic β-cells remain open, maintaining membrane hyperpolarization, Ca2+ channel closure and inhibiting insulin secretion. A rise in blood glucose (right-hand panel) drives oxidative phosphorylation and ATP production, resulting in the closure of KATP channels, plasma membrane depolarization, calcium influx and insulin vesicle exocytosis

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