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Figure 3 | BMC Biology

Figure 3

From: A chromatin code for alternative splicing involving a putative association between CTCF and HP1α proteins

Figure 3

Read profiles on regulated events. Density differences between MCF7 and MCF10, measured as the log2-ratio of RPKM values (y-axis) in (A) the I2 region for CTCF in skipped exons (red), inclusion exons (blue) and non-regulated exons (gray) (Kolmogorov-Smirnov test P-value <0.01 for all comparisons); and in (B) the region w5 for HP1α, in skipped exons (red), inclusion exons (blue) and non-regulated exons (gray) (Kolmogorov-Smirnov test P-value <0.01 for all comparisons). Profiles for HP1α and CTCF in MCF7 (C) and MCF10 (D) around 5′ splice-sites. The profiles show the mean read densities (y-axis) from -600 bp to 600 bp (x-axis) centered at the 5′ss of the regulated alternative exon (E2) for both ChIP-Seq samples, separately for skipped exons (red), included exons (blue) and non-regulated exons (gray). ChIP-Seq, chromatin immunoprecipitation-sequencing; CTCF, CCCTC-binding factor; HP1, heterochromatin protein 1.

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