Fig. 7From: Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activationA speculative model in which NM1 coordinates the local remodeling and maintenance of active epigenetic marks for transcription activation of class II promoters. a NM1 interacts with actin bound to Pol II via the two core subunits Rpb6 and Rpb8. b NM1 can also interact with SNF2h, thus facilitating B-WICH assembly to promote remodeling. We speculate that the NM1-actin and NM1-SNF2h interactions may depend on the ATPase activity of NM1 and may exclude each other. c This is followed by the establishment of H3K9ac, H3K27ac and H3K4me3 through NM1-mediated recruitment of the HAT PCAF and the HMT Set1/Ash2 that ultimately leads to transcription activation HAT histone acetyl transferase, HMT histone methyl transferase, NM1 nuclear myosin 1cBack to article page