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Fig. 7 | BMC Biology

Fig. 7

From: Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation

Fig. 7

A speculative model in which NM1 coordinates the local remodeling and maintenance of active epigenetic marks for transcription activation of class II promoters. a NM1 interacts with actin bound to Pol II via the two core subunits Rpb6 and Rpb8. b NM1 can also interact with SNF2h, thus facilitating B-WICH assembly to promote remodeling. We speculate that the NM1-actin and NM1-SNF2h interactions may depend on the ATPase activity of NM1 and may exclude each other. c This is followed by the establishment of H3K9ac, H3K27ac and H3K4me3 through NM1-mediated recruitment of the HAT PCAF and the HMT Set1/Ash2 that ultimately leads to transcription activation HAT histone acetyl transferase, HMT histone methyl transferase, NM1 nuclear myosin 1c

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