TY - JOUR AU - Luo, Yongfeng AU - El Agha, Elie AU - Turcatel, Gianluca AU - Chen, Hui AU - Chiu, Joanne AU - Warburton, David AU - Bellusci, Saverio AU - Qian, Bang-Ping AU - Menke, Douglas B. AU - Shi, Wei PY - 2015 DA - 2015/06/20 TI - Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development JO - BMC Biology SP - 42 VL - 13 IS - 1 AB - Adenomatous polyposis coli (Apc) is a tumor suppressor that inhibits Wnt/Ctnnb1. Mutations of Apc will not only lead to familial adenomatous polyposis with associated epithelial lesions, but will also cause aggressive fibromatosis in mesenchymal cells. However, the roles of Apc in regulating mesenchymal cell biology and organogenesis during development are unknown. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-015-0153-1 DO - 10.1186/s12915-015-0153-1 ID - Luo2015 ER -