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Fig. 7 | BMC Biology

Fig. 7

From: Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development

Fig. 7

Abrogation of Apc altered lung mesenchymal cell differentiation. a Deficient smooth muscle cell differentiation, detected by SMA immunostaining, was observed in both proximal airways (a) and vasculature (v) of E13.5 Apc CKO lung, which were marked by positively stained Sox2 and PECAM1, respectively. b Abnormal Sox9 expression was seen in the mesenchymal cells disseminated in peripheral lung of Apc CKO after E12.5. Lung epithelial cells were marked by cytokeratin staining. Cell nuclei were counterstained with DAPI (blue). *Hematopoietic cells with non-specific autofluorescence in E11.5 lungs

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